Reversibly Functionalizable Hydrogen Peroxide- Sensitive Asymmetric Nanopores

We describe the fabrication of a chemical-sensitive nanofluidic device based on asymmetric nanopores whose transport characteristics can be modulated upon exposure to hydrogen peroxide (H2O2). We show experimentally and theoretically that the current–voltage curves provide a suitable method to monitor the change of pore surface characteristics induced by H2O2 in solution from the electronic readouts. We demonstrate also that the single pore characteristics can be scaled to the case of a multipore membrane whose electric outputs can be readily controlled. Because H2O2 is an agent significant for medical diagnostics, the results should be useful for sensing nanofluidic devices. *Address correspondence to [email protected]